The problem
Written by Administrator   
Tuesday, 15 January 2008

The common carp is the third most important farmed freshwater fish species in the world. Eastern European carp genebanks have been responsible for the selective improvement of carp for intensive and semi-intensive pond culture in Europe and their dissemination worldwide. Several serious disease problems such as Koi herpesvirus (KHV), and erythrodermatitis (Aeromonas salmonicida and A. hydrophila) threaten carp farming in many countries.

Last Updated ( Monday, 07 February 2011 )
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Overview
Written by Administrator   
Tuesday, 15 January 2008

The use of marker assisted selection to increase disease resistance is a strategy that has the potential to enhance genetic progress with breeding for increased disease resistance (R?ed et al. 1992). Numerous studies on genetic variation in immune response in fish suggest that certain immune parameters may have some potential as practical markers for disease resistance (Balfry et al. 1994, Fevolden et al. 1994; Lund et al., 1995a, 1995b; Wiergertjes, et al, 1995. Specific (humoral antibody and antibody producing cells) and non-specific (lysozyme, macrophage function, blood cell counts) immune parameters may indicate disease resistance to viral or bacterial pathogens can be measured directly. Other genes can be identified using a proteomic approach. Comparison of protein expression in healthy and diseased tissue can pinpoint, which of the thousands of proteins are more or less active at any one time. This will lead to an understanding of the molecular basis of disease. Therefore characterising proteins and understanding their function is important to understand the disease process and may also assist in identifying specific molecules that are involved in disease resistance. These may be molecules involved in the immune response to infection or other stressors. DIGE is the method best suited to this task, involving a comparison of the spots produced in 2 dimensional electrophoresis of serum/plasma for healthy and disease fish. Spot analyses can then identify specific molecules.

Last Updated ( Friday, 24 April 2009 )
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Contribution to policy development
Written by Administrator   
Tuesday, 15 January 2008

The results of the project will be manifest in several different areas: economic, leisure activities/quality of life and the environment. The primary importance will be in identifying strains or families of carp, resistant to two serious pathogens, that can be used in future breeding programmes. Disease-resistant fish developed by such breeding programmes, using the techniques developed by this project, will make the livelihoods of carp farmers world-wide more secure, by limiting the occurrence and intensity of losses due to disease outbreaks. Inclusion of both disease resistance and other major traits (e.g. harvest size) in selection indices will help to develop fish that are both disease resistant and grow well. Those fish (or the techniques developed by the project) can be distributed world-wide, both to countries in which the diseases are endemic as a means of replacing lost stock, and to those countries in which the pathogens are not present as a means of limiting the spread of the diseases.

Last Updated ( Friday, 03 October 2008 )
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